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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
LDHA_HUMAN
USC-OGP 2-DE database
:
LDHA_HUMAN
LDHA_HUMAN
General information about the entry
View entry in simple text format
Entry name
LDHA_HUMAN
Primary accession number
P00338
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=L-lactate dehydrogenase A chain; Short=LDH-A; EC=1.1.1.27; AltName: Full=Cell proliferation-inducing gene 19 protein; AltName: Full=LDH muscle subunit; Short=LDH-M; AltName: Full=Renal carcinoma antigen NY-REN-59;.
Gene name
Name=LDHA
ORFNames=PIG19
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_4-7
{PLATELET 4-7}
Homo sapiens (Human)
map experimental info
PLATELET_4-7
MAP LOCATIONS:
SPOT OGP-0448
:
pI=5.54; Mw=35854
PLATELET_5-6
{PLATELET 5-6}
Homo sapiens (Human)
map experimental info
PLATELET_5-6
MAP LOCATIONS:
SPOT OGP-0736
:
pI=5.56; Mw=35605
PLATELET_6-11
{PLATELET 6-11}
Homo sapiens (Human)
map experimental info
PLATELET_6-11
MAP LOCATIONS:
SPOT OGP-0983
:
pI=7.83; Mw=32433
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1218
:
pI=5.73; Mw=36260
SPOT OGP-1225
:
pI=7.94; Mw=35254
Cross-references
UniProtKB/Swiss-Prot
P00338; LDHA_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
LDHA_HUMAN
Primary accession number
P00338
Secondary accession number(s)
B4DKQ2 B7Z5E3 D3DQY3 F8W819 Q53G53 Q6IBM7 Q6ZNV1 Q9UDE8 Q9UDE9
Sequence was last modified on
January 23, 2007 (version 2)
Annotations were last modified on
March 15, 2017 (version 208)
Name and origin of the protein
Description
RecName: Full=L-lactate dehydrogenase A chain; Short=LDH-A; EC=1.1.1.27; AltName: Full=Cell proliferation-inducing gene 19 protein; AltName: Full=LDH muscle subunit; Short=LDH-M; AltName: Full=Renal carcinoma antigen NY-REN-59;
Gene name
Name=LDHA
ORFNames=PIG19
Encoded on
Name=LDHA; ORFNames=PIG19
Keywords
3D-structure
;
Acetylation
;
Alternative splicing
;
Complete proteome
;
Cytoplasm
;
Direct protein sequencing
;
Disease mutation
;
Glycogen storage disease
;
NAD
;
Oxidoreductase
;
Phosphoprotein
;
Polymorphism
;
Reference proteome
;
Ubl conjugation
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
X02152; CAA26088.1
; -; mRNA
EMBL
X03077; CAA26879.1
; -; Genomic_DNA
EMBL
X03078; CAA26879.1
; JOINED; Genomic_DNA
EMBL
X03079; CAA26879.1
; JOINED; Genomic_DNA
EMBL
X03080; CAA26879.1
; JOINED; Genomic_DNA
EMBL
X03081; CAA26879.1
; JOINED; Genomic_DNA
EMBL
X03082; CAA26879.1
; JOINED; Genomic_DNA
EMBL
X03083; CAA26879.1
; JOINED; Genomic_DNA
EMBL
AY423727; AAS00490.1
; -; mRNA
EMBL
AK130587; BAC85389.1
; -; mRNA
EMBL
AK296667; BAG59264.1
; -; mRNA
EMBL
AK298834; BAH12879.1
; -; mRNA
EMBL
CR456775; CAG33056.1
; -; mRNA
EMBL
CR541714; CAG46515.1
; -; mRNA
EMBL
AK223078; BAD96798.1
; -; mRNA
EMBL
AC084117; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
CH471064; EAW68395.1
; -; Genomic_DNA
EMBL
CH471064; EAW68396.1
; -; Genomic_DNA
EMBL
BC067223; AAH67223.1
; -; mRNA
EMBL
S66853; AAB20418.1
; -; Genomic_DNA
CCDS
CCDS44549.1; -. [P00338-4]
; .
CCDS
CCDS53609.1; -. [P00338-3]
; .
CCDS
CCDS53610.1; -. [P00338-2]
; .
CCDS
CCDS53611.1; -. [P00338-5]
; .
CCDS
CCDS7839.1; -. [P00338-1]
; .
PIR
A00347; DEHULM
; .
RefSeq
NP_001128711.1; NM_001135239.1. [P00338-4]
; .
RefSeq
NP_001158886.1; NM_001165414.1. [P00338-3]
; .
RefSeq
NP_001158887.1; NM_001165415.1. [P00338-2]
; .
RefSeq
NP_001158888.1; NM_001165416.1. [P00338-5]
; .
RefSeq
NP_005557.1; NM_005566.3. [P00338-1]
; .
UniGene
Hs.2795; -
; .
PDB
1I10; X-ray
; 2.30 A; A/B/C/D/E/F/G/H=2-332
PDB
4AJP; X-ray
; 2.38 A; A/B/C/D=2-332
PDB
4JNK; X-ray
; 1.90 A; A/B/C/D=2-332
PDB
4L4R; X-ray
; 2.10 A; A/H=2-332
PDB
4L4S; X-ray
; 2.90 A; A/H=2-332
PDB
4M49; X-ray
; 2.05 A; A/B/C/D=2-332
PDB
4OJN; X-ray
; 2.40 A; A/B/C/D/E/F/G/H=2-332
PDB
4OKN; X-ray
; 2.10 A; A/B/C/D/E/F/G/H=2-332
PDB
4QO7; X-ray
; 2.14 A; A/B/C/D=2-332
PDB
4QO8; X-ray
; 2.00 A; A/B/C/D=2-332
PDB
4QSM; X-ray
; 3.00 A; A/B/C/D/E/F/G/H=2-332
PDB
4QT0; X-ray
; 3.20 A; A/B/C/D/E/F/G/H=2-332
PDB
4R68; X-ray
; 2.11 A; A/B/C/D=2-332
PDB
4R69; X-ray
; 3.19 A; A/B/C/D=2-332
PDB
4RLS; X-ray
; 1.91 A; A/B/C/D=2-332
PDB
4ZVV; X-ray
; 2.20 A; A/B/C/D=1-332
PDB
5IXS; X-ray
; 2.05 A; A/B/C/D=2-332
PDB
5IXY; X-ray
; 3.00 A; A/B/C/D=2-332
PDBsum
1I10; -
; .
PDBsum
4AJP; -
; .
PDBsum
4JNK; -
; .
PDBsum
4L4R; -
; .
PDBsum
4L4S; -
; .
PDBsum
4M49; -
; .
PDBsum
4OJN; -
; .
PDBsum
4OKN; -
; .
PDBsum
4QO7; -
; .
PDBsum
4QO8; -
; .
PDBsum
4QSM; -
; .
PDBsum
4QT0; -
; .
PDBsum
4R68; -
; .
PDBsum
4R69; -
; .
PDBsum
4RLS; -
; .
PDBsum
4ZVV; -
; .
PDBsum
5IXS; -
; .
PDBsum
5IXY; -
; .
ProteinModelPortal
P00338; -
; .
SMR
P00338; -
; .
BioGrid
110131; 143
; .
IntAct
P00338; 33
; .
MINT
MINT-4998672; -
; .
STRING
9606.ENSP00000445175; -
; .
BindingDB
P00338; -
; .
ChEMBL
CHEMBL4835; -
; .
DrugBank
DB02483; Etheno-Nad
; .
DrugBank
DB00157; NADH
; .
DrugBank
DB02701; Nicotinamide
; .
DrugBank
DB03940; Oxamic Acid
; .
iPTMnet
P00338; -
; .
PhosphoSitePlus
P00338; -
; .
SwissPalm
P00338; -
; .
BioMuta
LDHA; -
; .
DMDM
126047; -
; .
DOSAC-COBS-2DPAGE
P00338; -
; .
OGP
P00338; -
; .
REPRODUCTION-2DPAGE
IPI00217966; -
; .
EPD
P00338; -
; .
PaxDb
P00338; -
; .
PeptideAtlas
P00338; -
; .
PRIDE
P00338; -
; .
TopDownProteomics
P00338-1; -. [P00338-1]
; .
TopDownProteomics
P00338-4; -. [P00338-4]
; .
TopDownProteomics
P00338-5; -. [P00338-5]
; .
DNASU
3939; -
; .
Ensembl
ENST00000227157; ENSP00000227157
; ENSG00000134333. [P00338-5]; .
Ensembl
ENST00000379412; ENSP00000368722
; ENSG00000134333. [P00338-1]; .
Ensembl
ENST00000396222; ENSP00000379524
; ENSG00000134333. [P00338-2]; .
Ensembl
ENST00000422447; ENSP00000395337
; ENSG00000134333. [P00338-1]; .
Ensembl
ENST00000430553; ENSP00000406172
; ENSG00000134333. [P00338-4]; .
Ensembl
ENST00000540430; ENSP00000445175
; ENSG00000134333. [P00338-3]; .
Ensembl
ENST00000542179; ENSP00000445331
; ENSG00000134333. [P00338-1]; .
GeneID
3939; -
; .
KEGG
hsa:3939; -
; .
UCSC
uc001mol.4; human. [P00338-1]
; .
CTD
3939; -
; .
DisGeNET
3939; -
; .
GeneCards
LDHA; -
; .
HGNC
HGNC:6535; LDHA
; .
HPA
CAB015336; -
; .
MalaCards
LDHA; -
; .
MIM
150000; gene
; .
MIM
612933; phenotype
; .
neXtProt
NX_P00338; -
; .
OpenTargets
ENSG00000134333; -
; .
Orphanet
284426; Glycogen storage disease due to lactate dehydrogenase M-subunit deficiency
; .
PharmGKB
PA30319; -
; .
eggNOG
KOG1495; Eukaryota
; .
eggNOG
COG0039; LUCA
; .
GeneTree
ENSGT00550000074541; -
; .
HOGENOM
HOG000213793; -
; .
HOVERGEN
HBG000462; -
; .
InParanoid
P00338; -
; .
KO
K00016; -
; .
OMA
NNEHRVL; -
; .
OrthoDB
EOG091G0HME; -
; .
PhylomeDB
P00338; -
; .
TreeFam
TF314963; -
; .
Reactome
R-HSA-70268; Pyruvate metabolism
; .
SABIO-RK
P00338; -
; .
SIGNOR
P00338; -
; .
UniPathway
UPA00554; UER00611
; .
ChiTaRS
LDHA; human
; .
EvolutionaryTrace
P00338; -
; .
GeneWiki
LDHA; -
; .
GenomeRNAi
3939; -
; .
PRO
PR:P00338; -
; .
Proteomes
UP000005640; Chromosome 11
; .
Bgee
ENSG00000134333; -
; .
CleanEx
HS_LDHA; -
; .
ExpressionAtlas
P00338; baseline and differential
; .
Genevisible
P00338; HS
; .
GO
GO:0005829; C:cytosol
; TAS:Reactome; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0016020; C:membrane
; IDA:UniProtKB; .
GO
GO:0005634; C:nucleus
; IDA:UniProtKB; .
GO
GO:0045296; F:cadherin binding
; IDA:BHF-UCL; .
GO
GO:0004459; F:L-lactate dehydrogenase activity
; NAS:UniProtKB; .
GO
GO:0051287; F:NAD binding
; IEA:Ensembl; .
GO
GO:0006096; P:glycolytic process
; NAS:UniProtKB; .
GO
GO:0006089; P:lactate metabolic process
; IEA:Ensembl; .
GO
GO:0019674; P:NAD metabolic process
; IEA:Ensembl; .
GO
GO:0043065; P:positive regulation of apoptotic process
; IEA:Ensembl; .
GO
GO:0048569; P:post-embryonic animal organ development
; IEA:Ensembl; .
GO
GO:0006090; P:pyruvate metabolic process
; TAS:Reactome; .
GO
GO:0051591; P:response to cAMP
; IEA:Ensembl; .
GO
GO:0042493; P:response to drug
; IEA:Ensembl; .
GO
GO:0043627; P:response to estrogen
; IEA:Ensembl; .
GO
GO:0009749; P:response to glucose
; IEA:Ensembl; .
GO
GO:0042542; P:response to hydrogen peroxide
; IEA:Ensembl; .
GO
GO:0001666; P:response to hypoxia
; IEA:Ensembl; .
GO
GO:0007584; P:response to nutrient
; IEA:Ensembl; .
GO
GO:0021762; P:substantia nigra development
; IEP:UniProtKB; .
Gene3D
3.40.50.720; -
; 1; .
Gene3D
3.90.110.10; -
; 1; .
HAMAP
MF_00488; Lactate_dehydrog
; 1; .
InterPro
IPR001557; L-lactate/malate_DH
; .
InterPro
IPR011304; L-lactate_DH
; .
InterPro
IPR018177; L-lactate_DH_AS
; .
InterPro
IPR022383; Lactate/malate_DH_C
; .
InterPro
IPR001236; Lactate/malate_DH_N
; .
InterPro
IPR015955; Lactate_DH/Glyco_Ohase_4_C
; .
InterPro
IPR016040; NAD(P)-bd_dom
; .
Pfam
PF02866; Ldh_1_C
; 1; .
Pfam
PF00056; Ldh_1_N
; 1; .
PIRSF
PIRSF000102; Lac_mal_DH
; 1; .
PRINTS
PR00086; LLDHDRGNASE
; .
SUPFAM
SSF51735; SSF51735
; 1; .
SUPFAM
SSF56327; SSF56327
; 1; .
TIGRFAMs
TIGR01771; L-LDH-NAD
; 1; .
PROSITE
PS00064; L_LDH
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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