USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: LDHA_HUMAN USC-OGP 2-DE database:  LDHA_HUMAN LDHA_HUMAN General information about the entry View entry in simple text format Entry name LDHA_HUMAN Primary accession number P00338 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=L-lactate dehydrogenase A chain; Short=LDH-A; EC=1.1.1.27; AltName: Full=Cell proliferation-inducing gene 19 protein; AltName: Full=LDH muscle subunit; Short=LDH-M; AltName: Full=Renal carcinoma antigen NY-REN-59;. Gene name Name=LDHA ORFNames=PIG19 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0448: pI=5.54; Mw=35854 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0736: pI=5.56; Mw=35605 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0983: pI=7.83; Mw=32433 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1218: pI=5.73; Mw=36260 SPOT OGP-1225: pI=7.94; Mw=35254 Cross-references UniProtKB/Swiss-Prot P00338; LDHA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name LDHA_HUMAN Primary accession number P00338 Secondary accession number(s) B4DKQ2 B7Z5E3 D3DQY3 F8W819 Q53G53 Q6IBM7 Q6ZNV1 Q9UDE8 Q9UDE9 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 208) Name and origin of the protein Description RecName: Full=L-lactate dehydrogenase A chain; Short=LDH-A; EC=1.1.1.27; AltName: Full=Cell proliferation-inducing gene 19 protein; AltName: Full=LDH muscle subunit; Short=LDH-M; AltName: Full=Renal carcinoma antigen NY-REN-59; Gene name Name=LDHA ORFNames=PIG19 Encoded on Name=LDHA; ORFNames=PIG19 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Glycogen storage disease; NAD; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X02152; CAA26088.1; -; mRNA EMBL X03077; CAA26879.1; -; Genomic_DNA EMBL X03078; CAA26879.1; JOINED; Genomic_DNA EMBL X03079; CAA26879.1; JOINED; Genomic_DNA EMBL X03080; CAA26879.1; JOINED; Genomic_DNA EMBL X03081; CAA26879.1; JOINED; Genomic_DNA EMBL X03082; CAA26879.1; JOINED; Genomic_DNA EMBL X03083; CAA26879.1; JOINED; Genomic_DNA EMBL AY423727; AAS00490.1; -; mRNA EMBL AK130587; BAC85389.1; -; mRNA EMBL AK296667; BAG59264.1; -; mRNA EMBL AK298834; BAH12879.1; -; mRNA EMBL CR456775; CAG33056.1; -; mRNA EMBL CR541714; CAG46515.1; -; mRNA EMBL AK223078; BAD96798.1; -; mRNA EMBL AC084117; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471064; EAW68395.1; -; Genomic_DNA EMBL CH471064; EAW68396.1; -; Genomic_DNA EMBL BC067223; AAH67223.1; -; mRNA EMBL S66853; AAB20418.1; -; Genomic_DNA CCDS CCDS44549.1; -. [P00338-4]; . CCDS CCDS53609.1; -. [P00338-3]; . CCDS CCDS53610.1; -. [P00338-2]; . CCDS CCDS53611.1; -. [P00338-5]; . CCDS CCDS7839.1; -. [P00338-1]; . PIR A00347; DEHULM; . RefSeq NP_001128711.1; NM_001135239.1. [P00338-4]; . RefSeq NP_001158886.1; NM_001165414.1. [P00338-3]; . RefSeq NP_001158887.1; NM_001165415.1. [P00338-2]; . RefSeq NP_001158888.1; NM_001165416.1. [P00338-5]; . RefSeq NP_005557.1; NM_005566.3. [P00338-1]; . UniGene Hs.2795; -; . PDB 1I10; X-ray; 2.30 A; A/B/C/D/E/F/G/H=2-332 PDB 4AJP; X-ray; 2.38 A; A/B/C/D=2-332 PDB 4JNK; X-ray; 1.90 A; A/B/C/D=2-332 PDB 4L4R; X-ray; 2.10 A; A/H=2-332 PDB 4L4S; X-ray; 2.90 A; A/H=2-332 PDB 4M49; X-ray; 2.05 A; A/B/C/D=2-332 PDB 4OJN; X-ray; 2.40 A; A/B/C/D/E/F/G/H=2-332 PDB 4OKN; X-ray; 2.10 A; A/B/C/D/E/F/G/H=2-332 PDB 4QO7; X-ray; 2.14 A; A/B/C/D=2-332 PDB 4QO8; X-ray; 2.00 A; A/B/C/D=2-332 PDB 4QSM; X-ray; 3.00 A; A/B/C/D/E/F/G/H=2-332 PDB 4QT0; X-ray; 3.20 A; A/B/C/D/E/F/G/H=2-332 PDB 4R68; X-ray; 2.11 A; A/B/C/D=2-332 PDB 4R69; X-ray; 3.19 A; A/B/C/D=2-332 PDB 4RLS; X-ray; 1.91 A; A/B/C/D=2-332 PDB 4ZVV; X-ray; 2.20 A; A/B/C/D=1-332 PDB 5IXS; X-ray; 2.05 A; A/B/C/D=2-332 PDB 5IXY; X-ray; 3.00 A; A/B/C/D=2-332 PDBsum 1I10; -; . PDBsum 4AJP; -; . PDBsum 4JNK; -; . PDBsum 4L4R; -; . PDBsum 4L4S; -; . PDBsum 4M49; -; . PDBsum 4OJN; -; . PDBsum 4OKN; -; . PDBsum 4QO7; -; . PDBsum 4QO8; -; . PDBsum 4QSM; -; . PDBsum 4QT0; -; . PDBsum 4R68; -; . PDBsum 4R69; -; . PDBsum 4RLS; -; . PDBsum 4ZVV; -; . PDBsum 5IXS; -; . PDBsum 5IXY; -; . ProteinModelPortal P00338; -; . SMR P00338; -; . BioGrid 110131; 143; . IntAct P00338; 33; . MINT MINT-4998672; -; . STRING 9606.ENSP00000445175; -; . BindingDB P00338; -; . ChEMBL CHEMBL4835; -; . DrugBank DB02483; Etheno-Nad; . DrugBank DB00157; NADH; . DrugBank DB02701; Nicotinamide; . DrugBank DB03940; Oxamic Acid; . iPTMnet P00338; -; . PhosphoSitePlus P00338; -; . SwissPalm P00338; -; . BioMuta LDHA; -; . DMDM 126047; -; . DOSAC-COBS-2DPAGE P00338; -; . OGP P00338; -; . REPRODUCTION-2DPAGE IPI00217966; -; . EPD P00338; -; . PaxDb P00338; -; . PeptideAtlas P00338; -; . PRIDE P00338; -; . TopDownProteomics P00338-1; -. [P00338-1]; . TopDownProteomics P00338-4; -. [P00338-4]; . TopDownProteomics P00338-5; -. [P00338-5]; . DNASU 3939; -; . Ensembl ENST00000227157; ENSP00000227157; ENSG00000134333. [P00338-5]; . Ensembl ENST00000379412; ENSP00000368722; ENSG00000134333. [P00338-1]; . Ensembl ENST00000396222; ENSP00000379524; ENSG00000134333. [P00338-2]; . Ensembl ENST00000422447; ENSP00000395337; ENSG00000134333. [P00338-1]; . Ensembl ENST00000430553; ENSP00000406172; ENSG00000134333. [P00338-4]; . Ensembl ENST00000540430; ENSP00000445175; ENSG00000134333. [P00338-3]; . Ensembl ENST00000542179; ENSP00000445331; ENSG00000134333. [P00338-1]; . GeneID 3939; -; . KEGG hsa:3939; -; . UCSC uc001mol.4; human. [P00338-1]; . CTD 3939; -; . DisGeNET 3939; -; . GeneCards LDHA; -; . HGNC HGNC:6535; LDHA; . HPA CAB015336; -; . MalaCards LDHA; -; . MIM 150000; gene; . MIM 612933; phenotype; . neXtProt NX_P00338; -; . OpenTargets ENSG00000134333; -; . Orphanet 284426; Glycogen storage disease due to lactate dehydrogenase M-subunit deficiency; . PharmGKB PA30319; -; . eggNOG KOG1495; Eukaryota; . eggNOG COG0039; LUCA; . GeneTree ENSGT00550000074541; -; . HOGENOM HOG000213793; -; . HOVERGEN HBG000462; -; . InParanoid P00338; -; . KO K00016; -; . OMA NNEHRVL; -; . OrthoDB EOG091G0HME; -; . PhylomeDB P00338; -; . TreeFam TF314963; -; . Reactome R-HSA-70268; Pyruvate metabolism; . SABIO-RK P00338; -; . SIGNOR P00338; -; . UniPathway UPA00554; UER00611; . ChiTaRS LDHA; human; . EvolutionaryTrace P00338; -; . GeneWiki LDHA; -; . GenomeRNAi 3939; -; . PRO PR:P00338; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000134333; -; . CleanEx HS_LDHA; -; . ExpressionAtlas P00338; baseline and differential; . Genevisible P00338; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0004459; F:L-lactate dehydrogenase activity; NAS:UniProtKB; . GO GO:0051287; F:NAD binding; IEA:Ensembl; . GO GO:0006096; P:glycolytic process; NAS:UniProtKB; . GO GO:0006089; P:lactate metabolic process; IEA:Ensembl; . GO GO:0019674; P:NAD metabolic process; IEA:Ensembl; . GO GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl; . GO GO:0048569; P:post-embryonic animal organ development; IEA:Ensembl; . GO GO:0006090; P:pyruvate metabolic process; TAS:Reactome; . GO GO:0051591; P:response to cAMP; IEA:Ensembl; . GO GO:0042493; P:response to drug; IEA:Ensembl; . GO GO:0043627; P:response to estrogen; IEA:Ensembl; . GO GO:0009749; P:response to glucose; IEA:Ensembl; . GO GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl; . GO GO:0001666; P:response to hypoxia; IEA:Ensembl; . GO GO:0007584; P:response to nutrient; IEA:Ensembl; . GO GO:0021762; P:substantia nigra development; IEP:UniProtKB; . Gene3D 3.40.50.720; -; 1; . Gene3D 3.90.110.10; -; 1; . HAMAP MF_00488; Lactate_dehydrog; 1; . InterPro IPR001557; L-lactate/malate_DH; . InterPro IPR011304; L-lactate_DH; . InterPro IPR018177; L-lactate_DH_AS; . InterPro IPR022383; Lactate/malate_DH_C; . InterPro IPR001236; Lactate/malate_DH_N; . InterPro IPR015955; Lactate_DH/Glyco_Ohase_4_C; . InterPro IPR016040; NAD(P)-bd_dom; . Pfam PF02866; Ldh_1_C; 1; . Pfam PF00056; Ldh_1_N; 1; . PIRSF PIRSF000102; Lac_mal_DH; 1; . PRINTS PR00086; LLDHDRGNASE; . SUPFAM SSF51735; SSF51735; 1; . SUPFAM SSF56327; SSF56327; 1; . TIGRFAMs TIGR01771; L-LDH-NAD; 1; . PROSITE PS00064; L_LDH; 1; .

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