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USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database


USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: LDHA_HUMAN




USC-OGP 2-DE database:  LDHA_HUMAN


LDHA_HUMAN


General information about the entry
View entry in simple text format
Entry nameLDHA_HUMAN
Primary accession numberP00338
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=L-lactate dehydrogenase A chain; Short=LDH-A; EC=1.1.1.27; AltName: Full=Cell proliferation-inducing gene 19 protein; AltName: Full=LDH muscle subunit; Short=LDH-M; AltName: Full=Renal carcinoma antigen NY-REN-59;.
Gene nameName=LDHA
ORFNames=PIG19
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]   2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

PLATELET_4-7 {PLATELET 4-7}
Homo sapiens (Human)
PLATELET_4-7
  map experimental info
 
PLATELET_4-7

MAP LOCATIONS:
pI=5.54; Mw=35854



PLATELET_5-6 {PLATELET 5-6}
Homo sapiens (Human)
PLATELET_5-6
  map experimental info
 
PLATELET_5-6

MAP LOCATIONS:
pI=5.56; Mw=35605



PLATELET_6-11 {PLATELET 6-11}
Homo sapiens (Human)
PLATELET_6-11
  map experimental info
 
PLATELET_6-11

MAP LOCATIONS:
pI=7.83; Mw=32433



UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10}
Homo sapiens (Human)
UVEAL_MELANOMA_3-10
  map experimental info
 
UVEAL_MELANOMA_3-10

MAP LOCATIONS:
pI=5.73; Mw=36260
pI=7.94; Mw=35254

Cross-references
UniProtKB/Swiss-ProtP00338; LDHA_HUMAN.



2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.



External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameLDHA_HUMAN
Primary accession numberP00338
Secondary accession number(s) B4DKQ2 B7Z5E3 D3DQY3 F8W819 Q53G53 Q6IBM7 Q6ZNV1 Q9UDE8 Q9UDE9
Sequence was last modified on January 23, 2007 (version 2)
Annotations were last modified on March 15, 2017 (version 208)
Name and origin of the protein
DescriptionRecName: Full=L-lactate dehydrogenase A chain; Short=LDH-A; EC=1.1.1.27; AltName: Full=Cell proliferation-inducing gene 19 protein; AltName: Full=LDH muscle subunit; Short=LDH-M; AltName: Full=Renal carcinoma antigen NY-REN-59;
Gene nameName=LDHA
ORFNames=PIG19
Encoded onName=LDHA; ORFNames=PIG19
Keywords3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Glycogen storage disease; NAD; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBLX02152; CAA26088.1; -; mRNA
EMBLX03077; CAA26879.1; -; Genomic_DNA
EMBLX03078; CAA26879.1; JOINED; Genomic_DNA
EMBLX03079; CAA26879.1; JOINED; Genomic_DNA
EMBLX03080; CAA26879.1; JOINED; Genomic_DNA
EMBLX03081; CAA26879.1; JOINED; Genomic_DNA
EMBLX03082; CAA26879.1; JOINED; Genomic_DNA
EMBLX03083; CAA26879.1; JOINED; Genomic_DNA
EMBLAY423727; AAS00490.1; -; mRNA
EMBLAK130587; BAC85389.1; -; mRNA
EMBLAK296667; BAG59264.1; -; mRNA
EMBLAK298834; BAH12879.1; -; mRNA
EMBLCR456775; CAG33056.1; -; mRNA
EMBLCR541714; CAG46515.1; -; mRNA
EMBLAK223078; BAD96798.1; -; mRNA
EMBLAC084117; -; NOT_ANNOTATED_CDS; Genomic_DNA
EMBLCH471064; EAW68395.1; -; Genomic_DNA
EMBLCH471064; EAW68396.1; -; Genomic_DNA
EMBLBC067223; AAH67223.1; -; mRNA
EMBLS66853; AAB20418.1; -; Genomic_DNA
CCDSCCDS44549.1; -. [P00338-4]; .
CCDSCCDS53609.1; -. [P00338-3]; .
CCDSCCDS53610.1; -. [P00338-2]; .
CCDSCCDS53611.1; -. [P00338-5]; .
CCDSCCDS7839.1; -. [P00338-1]; .
PIRA00347; DEHULM; .
RefSeqNP_001128711.1; NM_001135239.1. [P00338-4]; .
RefSeqNP_001158886.1; NM_001165414.1. [P00338-3]; .
RefSeqNP_001158887.1; NM_001165415.1. [P00338-2]; .
RefSeqNP_001158888.1; NM_001165416.1. [P00338-5]; .
RefSeqNP_005557.1; NM_005566.3. [P00338-1]; .
UniGeneHs.2795; -; .
PDB1I10; X-ray; 2.30 A; A/B/C/D/E/F/G/H=2-332
PDB4AJP; X-ray; 2.38 A; A/B/C/D=2-332
PDB4JNK; X-ray; 1.90 A; A/B/C/D=2-332
PDB4L4R; X-ray; 2.10 A; A/H=2-332
PDB4L4S; X-ray; 2.90 A; A/H=2-332
PDB4M49; X-ray; 2.05 A; A/B/C/D=2-332
PDB4OJN; X-ray; 2.40 A; A/B/C/D/E/F/G/H=2-332
PDB4OKN; X-ray; 2.10 A; A/B/C/D/E/F/G/H=2-332
PDB4QO7; X-ray; 2.14 A; A/B/C/D=2-332
PDB4QO8; X-ray; 2.00 A; A/B/C/D=2-332
PDB4QSM; X-ray; 3.00 A; A/B/C/D/E/F/G/H=2-332
PDB4QT0; X-ray; 3.20 A; A/B/C/D/E/F/G/H=2-332
PDB4R68; X-ray; 2.11 A; A/B/C/D=2-332
PDB4R69; X-ray; 3.19 A; A/B/C/D=2-332
PDB4RLS; X-ray; 1.91 A; A/B/C/D=2-332
PDB4ZVV; X-ray; 2.20 A; A/B/C/D=1-332
PDB5IXS; X-ray; 2.05 A; A/B/C/D=2-332
PDB5IXY; X-ray; 3.00 A; A/B/C/D=2-332
PDBsum1I10; -; .
PDBsum4AJP; -; .
PDBsum4JNK; -; .
PDBsum4L4R; -; .
PDBsum4L4S; -; .
PDBsum4M49; -; .
PDBsum4OJN; -; .
PDBsum4OKN; -; .
PDBsum4QO7; -; .
PDBsum4QO8; -; .
PDBsum4QSM; -; .
PDBsum4QT0; -; .
PDBsum4R68; -; .
PDBsum4R69; -; .
PDBsum4RLS; -; .
PDBsum4ZVV; -; .
PDBsum5IXS; -; .
PDBsum5IXY; -; .
ProteinModelPortalP00338; -; .
SMRP00338; -; .
BioGrid110131; 143; .
IntActP00338; 33; .
MINTMINT-4998672; -; .
STRING9606.ENSP00000445175; -; .
BindingDBP00338; -; .
ChEMBLCHEMBL4835; -; .
DrugBankDB02483; Etheno-Nad; .
DrugBankDB00157; NADH; .
DrugBankDB02701; Nicotinamide; .
DrugBankDB03940; Oxamic Acid; .
iPTMnetP00338; -; .
PhosphoSitePlusP00338; -; .
SwissPalmP00338; -; .
BioMutaLDHA; -; .
DMDM126047; -; .
DOSAC-COBS-2DPAGEP00338; -; .
OGPP00338; -; .
REPRODUCTION-2DPAGEIPI00217966; -; .
EPDP00338; -; .
PaxDbP00338; -; .
PeptideAtlasP00338; -; .
PRIDEP00338; -; .
TopDownProteomicsP00338-1; -. [P00338-1]; .
TopDownProteomicsP00338-4; -. [P00338-4]; .
TopDownProteomicsP00338-5; -. [P00338-5]; .
DNASU3939; -; .
EnsemblENST00000227157; ENSP00000227157; ENSG00000134333. [P00338-5]; .
EnsemblENST00000379412; ENSP00000368722; ENSG00000134333. [P00338-1]; .
EnsemblENST00000396222; ENSP00000379524; ENSG00000134333. [P00338-2]; .
EnsemblENST00000422447; ENSP00000395337; ENSG00000134333. [P00338-1]; .
EnsemblENST00000430553; ENSP00000406172; ENSG00000134333. [P00338-4]; .
EnsemblENST00000540430; ENSP00000445175; ENSG00000134333. [P00338-3]; .
EnsemblENST00000542179; ENSP00000445331; ENSG00000134333. [P00338-1]; .
GeneID3939; -; .
KEGGhsa:3939; -; .
UCSCuc001mol.4; human. [P00338-1]; .
CTD3939; -; .
DisGeNET3939; -; .
GeneCardsLDHA; -; .
HGNCHGNC:6535; LDHA; .
HPACAB015336; -; .
MalaCardsLDHA; -; .
MIM150000; gene; .
MIM612933; phenotype; .
neXtProtNX_P00338; -; .
OpenTargetsENSG00000134333; -; .
Orphanet284426; Glycogen storage disease due to lactate dehydrogenase M-subunit deficiency; .
PharmGKBPA30319; -; .
eggNOGKOG1495; Eukaryota; .
eggNOGCOG0039; LUCA; .
GeneTreeENSGT00550000074541; -; .
HOGENOMHOG000213793; -; .
HOVERGENHBG000462; -; .
InParanoidP00338; -; .
KOK00016; -; .
OMANNEHRVL; -; .
OrthoDBEOG091G0HME; -; .
PhylomeDBP00338; -; .
TreeFamTF314963; -; .
ReactomeR-HSA-70268; Pyruvate metabolism; .
SABIO-RKP00338; -; .
SIGNORP00338; -; .
UniPathwayUPA00554; UER00611; .
ChiTaRSLDHA; human; .
EvolutionaryTraceP00338; -; .
GeneWikiLDHA; -; .
GenomeRNAi3939; -; .
PROPR:P00338; -; .
ProteomesUP000005640; Chromosome 11; .
BgeeENSG00000134333; -; .
CleanExHS_LDHA; -; .
ExpressionAtlasP00338; baseline and differential; .
GenevisibleP00338; HS; .
GOGO:0005829; C:cytosol; TAS:Reactome; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0016020; C:membrane; IDA:UniProtKB; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0045296; F:cadherin binding; IDA:BHF-UCL; .
GOGO:0004459; F:L-lactate dehydrogenase activity; NAS:UniProtKB; .
GOGO:0051287; F:NAD binding; IEA:Ensembl; .
GOGO:0006096; P:glycolytic process; NAS:UniProtKB; .
GOGO:0006089; P:lactate metabolic process; IEA:Ensembl; .
GOGO:0019674; P:NAD metabolic process; IEA:Ensembl; .
GOGO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl; .
GOGO:0048569; P:post-embryonic animal organ development; IEA:Ensembl; .
GOGO:0006090; P:pyruvate metabolic process; TAS:Reactome; .
GOGO:0051591; P:response to cAMP; IEA:Ensembl; .
GOGO:0042493; P:response to drug; IEA:Ensembl; .
GOGO:0043627; P:response to estrogen; IEA:Ensembl; .
GOGO:0009749; P:response to glucose; IEA:Ensembl; .
GOGO:0042542; P:response to hydrogen peroxide; IEA:Ensembl; .
GOGO:0001666; P:response to hypoxia; IEA:Ensembl; .
GOGO:0007584; P:response to nutrient; IEA:Ensembl; .
GOGO:0021762; P:substantia nigra development; IEP:UniProtKB; .
Gene3D3.40.50.720; -; 1; .
Gene3D3.90.110.10; -; 1; .
HAMAPMF_00488; Lactate_dehydrog; 1; .
InterProIPR001557; L-lactate/malate_DH; .
InterProIPR011304; L-lactate_DH; .
InterProIPR018177; L-lactate_DH_AS; .
InterProIPR022383; Lactate/malate_DH_C; .
InterProIPR001236; Lactate/malate_DH_N; .
InterProIPR015955; Lactate_DH/Glyco_Ohase_4_C; .
InterProIPR016040; NAD(P)-bd_dom; .
PfamPF02866; Ldh_1_C; 1; .
PfamPF00056; Ldh_1_N; 1; .
PIRSFPIRSF000102; Lac_mal_DH; 1; .
PRINTSPR00086; LLDHDRGNASE; .
SUPFAMSSF51735; SSF51735; 1; .
SUPFAMSSF56327; SSF56327; 1; .
TIGRFAMsTIGR01771; L-LDH-NAD; 1; .
PROSITEPS00064; L_LDH; 1; .



USC-OGP 2-DE database image


Gateways to other related servers


Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server

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